Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Polymyxin B and Tubocurarine

supplement:

Tubocurarine

Research Papers that Mention the Interaction

Polymyxin B causes neostigmine resistance to d-tubocurarine blockade and calcium resistance to the blockade evoked by aminoglycosidic antibiotics.
Arzneimittel-Forschung  •  1982  |  View Paper
When both d-Tc and neomycin or polymyxin B were added the increase of the NM effect of lidocaine was even greater (p < 0.001).
Anesthesia and analgesia  •  1980  |  View Paper
Polymyxin B (5 μg/ml) did not affect twitch tension alone but decreased the pancuronium ED, from 0.8 μg/ml to 0.32 μg/ml and the d-tubocurarine ED30 from 0.25 μg/ml to 0.15 μg/ml.
The authors conclude that polymyxin B potentiates the neuromuscular blockade from pancuronium or d-tubocurarine and that neostigmine further augments this block.
Anesthesia and analgesia  •  1976  |  View Paper