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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Polymyxin B
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“ Polymyxin B causes neostigmine resistance to d-tubocurarine blockade and calcium resistance to the blockade evoked by aminoglycosidic antibiotics.”
Arrest of respiration induced by polypeptide antibiotics.“When both d-Tc and neomycin or polymyxin B were added the increase of the NM effect of lidocaine was even greater (p < 0.001).”
“ Polymyxin B (5 μg/ml) did not affect twitch tension alone but decreased the pancuronium ED, from 0.8 μg/ml to 0.32 μg/ml and the d-tubocurarine ED30 from 0.25 μg/ml to 0.15 μg/ml.”
“The authors conclude that polymyxin B potentiates the neuromuscular blockade from pancuronium or d-tubocurarine and that neostigmine further augments this block.”
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