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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Polymyxin B
supplement:
Potassium
Research Papers that Mention the Interaction
“ Polymyxin B (10(-4) mol/l), a blocker of protein kinase C, depresses the potassium current sensitive to extracellular calcium ions.”
[Pharmacologic and metabolic dependence of the delayed inactivated potassium outward current in the somatic membrane of snail neurons].“Second, polymyxin B (less than or equal to 0.1 mM) causes a reduction in net uptake of calcium, and slows the efflux of both calcium and potassium.”
“This report describes the case of a patient prescribed polymyxin B to treat a surgical wound infection, which led to significant increases in fractional excretion of calcium, magnesium, and potassium and subsequent persistent decreases in the levels of these ions, with serious consequences for the patient.”
Polymyxin Acute Kidney Injury: a case of severe tubulopathy.
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