Possible Interaction: Polymyxin B and Adrenocorticotropic Hormone

“Inhibition of the steroidogenic response to ACTH by a fixed concentration (20 microM) of polymyxin B is overcome by high concentrations of ACTH.”

“ Polymyxin B also partially inhibits the increased production of the cyclic nucleotide produced by ACTH.”

“ Polymyxin B produces a biphasic effect on the stimulation of steroid synthesis by 2 nM ACTH in these cells, with inhibition at low concentrations (less than 10 microM) and a return to control levels at high concentrations (greater than 100 microM).”

“ Polymyxin B , like ACTH, promotes rounding of Y-1 cells and partially inhibits rounding produced by ACTH.”