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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Vitamin C
Research Papers that Mention the Interaction
“To fully endorse the results stated above, combinatorial therapy of intravenous high dose vitamin C and PARP inhibitors needs to be reviewed in broader cohorts of patients.”
Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients“Consistently with these results, the addition of PARP inhibitors , such as thymidine and 3-aminobenzamide, during the preincubation with AA , prevents NAD+ depletion and abolishes the protective effect of AA against apoptosis.”
Protection by ascorbate against apoptosis of thymocytes: implications of ascorbate-induced nonlethal oxidative stress and poly(ADP-ribosyl)ation.“Furthermore, PARPi enhance the in vitro efficacy of azacitidine, decitabine, and high-dose vitamin C , all agents that alter DNA methylation.”
“In combination with vitamin C, PARPi increase the levels of 5-hydroxymethylcytosine, likely as a result of altered processing of the oxidized intermediates associated with DNA demethylation.”
Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide–Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C
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