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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pirenzepine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The secretagogue acetylcholine (ACh) stimulated calcium mobilization from intracellular calcium stores at the base … EC50 of 14 μM. The muscarinic receptor antagonists 4‐DAMP, AF‐DX 384, pirenzepine … calcium signal with the following respective IC50 (pKb) values: 0.78 nM (…), 128 nM (7.1), and 2510 nM (5.8).”
The colon‐selective spasmolytic otilonium bromide inhibits muscarinic M3 receptor‐coupled calcium signals in isolated human colonic crypts“The Ca2+ response could partially be blocked by atropine and completely by pirenzepine , a specific muscarinic receptor-type M1 antagonist.”
“The carbachol effects depended on the calcium concentration and were competitively inhibited by pirenzepine.”
Subclasses of muscarinic receptors in isolated gastric mucosal cells: receptor characterization and parietal cell function.
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