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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Piperazine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“The distinct inhibitory action of ascorbic acid was verified under simulated conditions of the human stomach in further 9 drugs undergoing nitrosation at different rates, which contain the active agents: aminophenazone, clomipramine, imipramine, desipramine, ampicilline, oxacilline, phenoxymethylpenicilline, ethambutole or piperazine.”
[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].“The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine , N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid.”
Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N-Nitroso Compounds
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