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“These results suggest that if serotonin availability and release is further enhanced by tryptophan in the presence of nefazodone and pindolol , an antidepressant effect may be produced in patients who are otherwise treatment-resistant.”
“The charge distribution on the indole nucleus of anotherβ-blocker, pindolol , with higher affinity for theβ-adrenoceptor, enables an even stronger interaction with the tryptophan residue.”