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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pinacidil
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Results suggest that gabapentin and pinacidil may activate Ca2+ -activated and ATP-sensitive K+ channels in order to produce part of its spinal antiallodynic effect in the Chung model.”
Effect of K+ channel modulators on the antiallodynic effect of gabapentin.“ Pinacidil , a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store.”
“ Pinacidil (0.1-100 microM) inhibited the increases in cytosolic Ca2+ ([Ca2+]i) and muscle tension due to norepinephrine in rat aorta.”
“In ring preparations of rabbit aorta exposed to calcium-free medium and then depolarized with potassium (127 mM), pinacidil , 5 x 10(-5) M and nifedipine, 10(-8) M significantly inhibited the contractions by cumulative addition of calcium.”
“ Pinacidil (100 µM) inhibited this increase in Ca2+ (85.3 ± 12.3 AU at the beginning of the experiment, 81.7 ± 11.0 AU at the end of the experiment; n = 13; P = 0.616).”
A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels“The Ca2+ -dependent TPeA and K+-evoked release of glutamate was inhibited by both cromakalim and pinacidil in a concentration-dependent fashion.”
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