supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The results suggest that the mechanisms by which pimozide and quinine reduce the hedonic quality of natural rewards are functionally dissimilar.”
The dopaminergic mediation of a sweet reward in normal and VMH hyperphagic rats“Several "taste reactivity" studies of dopamine and reward have concluded that pimozide suppresses the hedonic reaction patterns normally elicited by sucrose but enhances aversive reaction patterns elicited by quinine.”
Pimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity“ Pimozide affected ingestion of quinine in many ways, but did not affect that of sucrose solution.”
“ Pimozide (4mg/kg, ip) also antagonised the antagonistic effect of d-amphetamine (4mg/kg, ip) on the antinociceptive effect of quinine (50mg/kg, ip).”
“ Pimozide (4mg/kg, ip), L-sulpiride (40mg/kg, ip), SCH 23390 (0.2mg/kg, sc) and alpha-methyl-p-tyrosine (50mg/kg, ip) effectively potentiated the antinociceptive effects of quinine (50mg/kg, ip).”
“ Pimozide (4 mg/kg, ip) significantly potentiated the protective effect of quinine (50-100 mg/kg, ip) against leptazol (80-90 mg/kg, sc)-induced seizure.”
“On the other hand, pimozide (0.2 mg/kg intraperitoneally), L-sulpiride (40 mg/kg intraperitoneally and SCH 23390 (0.2 mg/kg subcutaneously) potentiated the locomotor depressant effect of high doses of quinine (1-5 mg/kg) intraperitoneally).”
Some behavioural effects of quinine in mice
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback