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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pimozide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Patients treated with pimozide were found to have a significant decreased in both calcium and magnesium compared with their drug-free values.”
Serum calcium and magnesium in schizophrenia: relationship to clinical phenomena and neuroleptic treatment.“… Ca2+ (… pimozide , but not that of verapamil and diltiazem, the weak activity of some of the antagonists as relaxants of Ca2+-induced contractions can be attributed … potency of drugs as “Ca2+-antagonists” are discussed and it is proposed that three subgroups of drugs may exist within the overall classification.”
Assessment of “Ca2+-antagonist” effects of drugs in K+-depolarized smooth muscle“Even if a blocking effect on alpha-adrenoceptors cannot be discarded, our results suggest that pimozide may interfere with calcium in the arterial smooth muscle.”
“The additional observation that pimozide inhibits Ca2+ ionophore (A23187 and ionomycin)-stimulated LH release suggests that the locus of pimozide action is after Ca2+ mobilization.”
“ Pimozide and the various structurally related compounds used, also antagonized Ca 2 + -induced smooth muscle contractions of the isolated caudal artery of the rat.”
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