Possible Interaction: Phytate and Calcium Supplement

“It was concluded that the inhibitory effect of phytate on the absorption of zinc and the retention of calcium was dose dependent.”

“Bioavailability of calcium is, however, compromised by phytate , which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization.”

“Because dietary fibers and some associated substances, such as phytate , have in vitro mineral-binding capacities, they have been thought to impair absorption of minerals such as calcium , iron and zinc, although magnesium absorption seems to be less affected.”

“As little as 40 mg Ca added to 80 g flour reduced phytate degradation by 50%, thus increasing the phytate content of the rolls to levels interfering with iron absorption.”

“ Calcium added to the dough when making the rolls reduced phytate degradation during fermentation and baking.”

“The addition of ionic calcium to technetium-99m stannous phytate produced an agent with improved splenic uptake.”

“Furthermore, phytate (IP6), a well-known antinutrient is present in concentration capable of hindering bioavailability of iron (Fe), zinc (Zn), calcium (Ca), phosphorus (P) and other micronutrients from the seeds.”

“Based on the hypotheses that (1) Ca and Fe both promote Zn absorption by binding with phytate and thereby making it unavailable for binding Zn and (2) protein enhances the availability of Zn for transporter binding, the model was modified to incorporate these effects.”

“Such foods are high in phytate , which limits the bioavailability of nutrients, including iron, calcium , zinc, and in some cases proteins, which are crucial to the development of infants.”

“There was a positive correlation between dietary calcium and dietary phytates (P < 0.001), dietary proteins (P < 0.001), dietary fat (P < 0.001), and total energy (P < 0.001).”

“ Phytate may impair the bioavailability of iron, calcium and zinc in the diets of people in China.”