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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Physostigmine
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“The ACh sensitivity of the preparations was increased by physostigmine and decreased or abolished byd-tubocurarine.”
Contractures in normal and denervated inferior oblique muscle of the rabbit“The responses activated by physostigmine were inhibited competitively by tubocurarine , which indicates that physostigmine interacts with the ACh site of locust nicotinic ACh receptors.”
“ d-Tubocurarine (DTC), a nicotinic receptor blocker, enhanced ACh release in the presence of physostigmine but proved to be ineffective in normal preparations.”
“This effect was mediated via prejunctional nicotinic receptor stimulation: (+)‐tubocurarine , pancuronium and pipecuronium completely prevented the effect of physostigmine.”
“In the chick biventer cervicis muscle, however, the tetanic contraction was well maintained and … to 0.42 to 0.53-0.69 microM. In the chick muscle, physostigmine … (+)tubocurarine for 70% block of the twitch response from 1.68 … 40-fold at the receptor site for exogenously applied ACh.”
“Their effects are inhibited by atropine and also by d-tubocurarine and potentiated by physostigmine.”
“On the frog rectus, physostigmine antagonised whereas d-tubocurarine and CaCl2 increased the imipramine-induced inhibition.”
“Whereas physostigmine antagonized the blocking effect of d-tubocurarine , it does not influence that of DMPP on peristaltic reflexes of the ileum.”
Effect of 1,1-Dimethyl-4-Phenylpiperazinium Iodide on Peristaltic Reflexes of Isolated Guinea Pig Ileum
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