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Last Updated: 2 years ago

Possible Interaction: Physostigmine and Procaine

supplement:

Procaine

Research Papers that Mention the Interaction

Pretreatment of muscles with 4 mM procaine reduces physostigmine's capacity to produce contracture, evidently by means of a competitive inhibition at SR sites.
Pflügers Archiv  •  2004  |  View Paper
Physostigmine produced dose-related decreases in the self-administration of both cocaine and procaine.
Pharmacology Biochemistry and Behavior  •  1982  |  View Paper
A variety of drugs was … spontaneous twitching induced by physostigmine without blocking neuromuscular transmission: d -tubocurarine (1.6 x 10-7 M), trihexyphenidyl (9.2 x 10-….0 x 10-5 M), atropine (2.6 to 5.2 x 10-5 M) and procaine (3.6 to …-5 M).
The Journal of pharmacology and experimental therapeutics  •  1963  |  View Paper
Physostigmine and DFP showed significant protective effects, increasing the LD 50 of procaine 23 and 16 per cent, respectively.
The Journal of pharmacology and experimental therapeutics  •  1949  |  View Paper
Physostigmine , dimethyl-carbamate of hydroxy-phenylbenzyl-trimethylammonium (Nu-683) or di-isopropylfluorophosphate (DFP) suppress the paralyzing effects of procaine on synapses, on postsynaptic cardiac innervation and on neuro-muscular junctions, while procaine protects against most symptoms of intoxication induced by physostigmine, Nu-683 or DFP.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1950  |  View Paper