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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Physostigmine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The greater the ACTH and AVP responses to PHYSO , the stronger their correlation, suggesting that AVP may have been acting as a secretagogue for ACTH.”
Hypothalamo–pituitary–adrenal cortical responses to low-dose physostigmine and arginine vasopressin administration: sex differences between major depressives and matched control subjects“High-dose physostigmine infusion that produced noxious side effects resulted in significant elevation above baseline in plasma levels of adrenocorticotrophic hormone (ACTH) (p = 0.0001), cortisol (p = 0.0001), and beta-endorphin (p = 0.0001).”
“Meal intake stimulated ACTH and cortisol secretion which was significantly enhanced when physostigmine was administered (p < 0.05).”
“Administration of physostigmine , unlike that of neostigmine, was associated with statistically significant increases in plasma concentrations of cortisol, prolactin, ACTH , beta-endorphin/beta-lipotropin-like immunoreactivity, and epinephrine, presumably via central mechanisms.”
“However, each subject had a marked increase in ACTH and cortisol levels after the largest dose of physostigmine.”
“These findings suggest that physostigmine stimulates ACTH and cortisol secretion through a stress-mediated effect rather than through a specific cholinergic mechanism.”
“ Physostigmine also elevated subjects' plasma ACTH levels, a marker of central cholinergic activity.”
The scopolamine model of dementia: determination of central cholinomimetic effects of physostigmine on cognition and biochemical markers in man
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