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Last Updated: 3 years ago

Possible Interaction: Phosphoserine and Serine

supplement:

Phosphoserine

supplement:

Serine

Research Papers that Mention the Interaction

Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.
Nature Communications  •  2019  |  View Paper
Serine in physiological concentrations inhibits P-serine phosphatase , the last reaction in the “phosphorylated pathway”.
Advances in enzyme regulation  •  1967  |  View Paper
Inhibition of P-serine phosphatase by l-serine may have physiological significance in mammals.
The Journal of biological chemistry  •  1966  |  View Paper
In addition, reactive DESI can be performed with ion/ion reactions of Zn(II) complexes for the selective binding of phosphoserine in the presence of serine.
Journal of the American Society for Mass Spectrometry  •  2009  |  View Paper
For optimal conditions the reaction of O-phosphoserine is faster by a factor of 10(4) in the velocity of the beta-elimination than the corresponding acid-catalyzed beta-elimination of serine.
Biochimica et biophysica acta  •  1976  |  View Paper