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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phospholipids
supplement:
Water-Soluble Vitamin
Research Papers that Mention the Interaction
“In vitro, detergents (Triton X-100 or bile acids) or negatively charged ganglioside or phospholipids and one of several "activator proteins" increase hydrolytic rate of lipid and water-soluble substrates.”
Acid beta-glucosidase: enzymology and molecular biology of Gaucher disease.“Another perspective uses water-soluble additives , such as electrolytes and hydrophilic polymers that are prone to enhance adsorption of phospholipids.”
“Importantly, our studies indicate that PLC-NPs may be a promising delivery system to enhance the oral bioavailability of highly water-soluble drugs.”
Mechanisms of phospholipid complex loaded nanoparticles enhancing the oral bioavailability.“ Water-soluble polymers such as dextran and polyethylene glycol are known to induce aggregation and size growth of phospholipid vesicles.”
Aggregation of phospholipid vesicles by water-soluble polymers.“ Water-soluble polymers , such as dextrans and polyethylene glycols (PEGs) of different molecular weights, induce reversible aggregation of phospholipid vesicles , mostly due to dehydration of the vesicle surface and depletion forces, and only at much higher concentrations, PEGs (but not dextran) also induce irreversible size growth of the vesicles.”
“By coadmixing a small amount of negatively charged phospholipids such as dipalmitoyl phosphatidylglycerol or dicetyl phosphate, the leakage of water-soluble NA was further prevented.”
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