Possible Interaction: Phospholipids and Vitamin E

“From such studies using a variety of biophysical methods, it has been shown that alpha-tocopherol intercalates into phospholipid bilayers with the long axis of the molecule oriented parallel to the lipid hydrocarbon chains.”

“Further, exogenous addition of graded amounts of alpha-tocopherol to the red cells, prior to the addition of either venoms, minimizes the venom-induced lysis and erythrocyte phospholipid splitting.”

“Pretreatment of either human or bovine erythrocytes with antioxidants such as vitamin E (2 mM) prevented both oxidant‐induced reorganization of phospholipids in the bilayer and enhancement of adherence to endothelial cells.”

“Secondly, vitamin E may control the formation of lipid hydroperoxides through its antioxidant function, as well as possibly entering into a structural relation with membrane phospholipids.”

“The solubilization capacities also depended on the composition of the mixed micelles: micelle solubilization of vitamin E was increased by the presence of phospholipid (DOPC), but did not depend strongly on the presence of free fatty acid (octanoic acid or linoleic acid).”

“The suppression of copper-promoted lipid oxidation that was observed in the presence of plasmalogen phospholipids plus alpha-tocopherol was greater than the sum of the protective effects elicited by the two substances alone.”

“In low-density lipoproteins (LDL) and micelles supplemented with plasmalogen phospholipids plus alpha-tocopherol , the peroxyl radical-promoted oxidation was additively diminished.”

“ Plasmalogen phospholipids and alpha-tocopherol protected each other from oxidative degradation.”

“ alpha-Tocopherol suppressed the decrease of the membrane phospholipids by peroxidation and suppressed also the production of malondialdehyde.”

“2 It has recently been shown that α‐tocopherol α‐Toc ) inhibits drug‐ and PL accumulation in cell cultures chronically exposed to the CAD, amiodarone.”

“5 The inhibitory effects of α‐Toc on CAD and PL accumulations depends on the ratio between CAD and α‐Toc concentrations in the medium.”

“At 48 h post, LDL apheresis induced an increase in these molecular species only in patients receiving vitamin E. In conclusion, the contents …. LDL apheresis raises the level of plasmalogen phospholipids in plasma, the increase persisting longer in patients supplemented with vitamin E. Supplementation with vitamin E … plasmalogen phospholipids ….”