Possible Interaction: Phospholipids and Vitamin D

“ Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids , and ApoE (P < .05 for all).”

“ Plasma phospholipids were significantly reduced with the two highest infecting doses on D3 , and returned to normal values by D9 with the highest infecting dose.”

“These results suggest that vitamin D metabolites modulate PA2 activity, change the composition of membrane phospholipids by altering fatty acid composition, and affect calcium transport.”

“The data indicate that 1,25‐dihydroxyvitamin D3 may enhance deacylation of hepatocyte phospholipids , perhaps by activation of phospholipase A activity.”

“Further analysis of the fatty acid composition … brush border membrane lipids showed that vitamin D3 treatment led to an increase of the proportion of … (18:1 and 18:2 in the total and phospholipid fraction ) and also shorter chain fatty acids in … lipid fractions in the absence of cadmium.”

“The results are interpreted in terms of a possible interaction of vitamin D with phospholipids in cell membranes and the potential effects of such an interaction on calcium binding by membrane systems.”