Possible Interaction: Phospholipids and Vitamin A

“In freshly … concentration of vitamin A correlated negatively with the percentage of 18:… 6 in plasma CE, TG and PL and with that of 20:4 omega 6 in platelets, and beta-carotene and alpha-… positive correlations with 18:2 omega 6 in most plasma lipid fractions and platelets.”

“Although vitamin A (retinol) and retinoic acid have been shown to enhance the synthesis of phospholipid surfactant components, their effect on surfactant-specific proteins is unclear.”

“ Vitamin A reduced the amounts of heart total phospholipids , phosphatidyl-choline and its tetraenoic species and of the hexaenoic species of phosphatidyl-ethanolamine.”

“When administering 200.000 IU of vitamin A the content of the phospholipid and free cholesterol identified fractions lowers significantly.”

“Van Bruggen and Straumfjord7, on the other hand, observed that long-term administration of large doses of vitamin A to patients raised their plasma cholesterol and phospholipid levels.”

“When the cells, previously labeled with [3H]inositol, are treated with all-trans-retinal , they exhibit a decrease in the levels of [3H]inositol phospholipids and an increase in the accumulation of [3H]inositol phosphates.”

“It is therefore suggested that retinol and α-tocopherol may influence the structure and stability of specific areas of biological membranes by their interaction with phospholipid molecules in the lipid bilayers of the membrane.”