Possible Interaction: Phospholipids and Ubiquinone

“… phospholipids of a mitochondrial fraction enriched in Complexes I and III, … distance between complexes, determines adherence to pool behavior for Coenzyme Q , but only at dilution higher than 1:5 (protein:phospholipids), whereas, at lower phospholipid … of NADH cytochrome c reductase is higher than expected by the pool equation.”

“The possibility of enhancing the rate of NADH oxidation by CoQ therapy is hindered by the fact that the CoQ concentration in mitochondria appears to be regulated by its mixability with the membrane phospholipids.”

“The catabolism of phospholipids under the action of ubiquinone and radiation was inhibited in the liver and, on the contrary, was activated in radiosensitive organs.”

“Pretreatment with coenzyme Q10 (E-0216, CoQ10), an antidetergent agent, prevented not only the development of mitochondrial dysfunction and the decrease in mitochondrial phospholipids but also the elevation of GOT, GPT, and mGOT although CoQ10 did not prevent the elevation of T-Bil and TBA levels.”

“The partition coefficients largely increased by cosonication of ubiquinones with phospholipids.”

“These small changes were reflected, in the presence of ubiquinol-10, by a decrease in resolution indicating that the interaction between coenzyme Q and phospholipids changed the motion of the lipids.”

“ CoQ10 incorporation resulted in a dramatic increase of the microviscosity of nanoliposomes and inhibited the peroxidation of phospholipid.”

“ CoQ10 disturbs not only the hydrophobic core of the membrane but also the region close to the hydrophilic headgroups of phospholipids.”

“ Ubiquinone-10 did not visibly affect the lamellar gel to lamellar liquid-crystalline phase transition of Ela2Gro-P-Etn, but it clearly perturbed the multicomponent lamellar liquid-crystalline to lamellar gel phase transition of the phospholipid.”

“No spectral shifts or significant broadening of any absorbances due to the phospholipid were detected at temperatures of 20 or 54 … antisymmetric C-H stretching vibration with temperature indicated that the gel-to-liquid-crystal-line phase-transition temperature of the phospholipid was lowered by … 15 mol% ubiquinone-10.”