Possible Interaction: Phospholipids and Tryptophan

“The outcomes of this study include findings that cholesterol greatly impacts IpaC association with … near the C-terminus) can greatly impact its in vivo activity, and interaction with phospholipid membranes … tryptophan residues introduced at specific sites within IpaC. These data, together … concerning IpaC and its insertion into phospholipid membranes.”

“The responses to quinine hydrochloride and L-tryptophan , which have a bitter taste, were reduced as the phospholipid concentration was increased, and the responses to the other taste substances were not affected by the phospholipids, as with the human sensation test.”

“The opposite alterations were recorded upon interaction of platelet membranes with H-12-V. Furthermore, a small shift towards longer wavelengths, which … can be accounted for by a decrease in the polarity of the ANS environment, and may suggest an enhanced contact of the membrane tryptophan … phospholipid fatty acids.”

“It suggests a diminished contact of membrane tryptophan with phospholipid fatty acids.”

“These results suggest that tryptophane residues and amino groups interact with phospholipids.”

“Strong fluorescence resonance energy transfer from Trp in rP172 to DNS‐bound‐phospholipid was observed, and fluorescence polarization studies indicated that rP172 interacted with the hydrophobic core region of model membranes.”

“Interactions between the tryptophans in the fusion peptide and phospholipid residues contribute to peptide orientation.”

“Our data show that there are specific interactions between tryptophan and either phospholipid or glycolipid in the dry state, as well as H-bonding interactions between the lipids and both solutes.”

“The fluorescence of the tryptophan residues of these peptides exhibits an increased quantum yield upon binding to phospholipid vesicles.”