Possible Interaction: Phospholipids and Tretinoin

“Furthermore, evidence for the formation of a condensation product between the photolyzed chromophore all-trans-retinal and phosphatidylethanolamine indicates that phospholipid may also participate in the movement of the retinoid in the membrane.”

“The aqueous production of the tear film can be decreased by certain psychotherapeutic agents (especially the older ones), while the phospholipidic component , produced by the Meibomian glands, can be markedly affected by retinoids.”

“The results demonstrate that different retinoids and phospholipids may have positive or negative cooperativity in PKC activation, thereby regulating its enzymatic activity and affecting the resulting intracellular activation events.”

“Conclusions: The isomeric position of the polyene chain and the presence of phospholipid in the micellar vehicle have a significant influence on the membrane transport of the retinoic acids.”

“Although vitamin A (retinol) and retinoic acid have been shown to enhance the synthesis of phospholipid surfactant components, their effect on surfactant-specific proteins is unclear.”

“The … all-trans-retinoic acid on … of phospholipids was concentration-dependent with significant effect occurring at 2.1 microM. The loss of labeled fatty acids from prelabeled phospholipids and … transport of labeled fatty acids into granulocytes were not responsive to the presence of retinoic acid in the incubation media.”

“ Retinoids can be incorporated into phospholipid bilayers and, at relatively low concentrations, can affect the basic membrane properties of permeability and lipid phase transition, with retinoic acid exerting a larger perturbing effect than retinol.”