Possible Interaction: Phospholipids and Trehalose

“ Trehalose lipid has been shown to have a great tendency to partition into phospholipid membranes ; therefore, the characterization of its interaction with biological membranes is of central importance.”

“The chemical composition of the phospholipids (PLs) has key consequences not only for their interaction with trehalose , as we demonstrate with Langmuir-Blodgett monolayers, but also, the kinetic response of PLs to hydration transients is strongly influenced as evidenced by time-resolved FTIR spectroscopy.”

“Because of the practical implications of these properties of trehalose , the mechanism of its interaction with membrane phospholipids is emphasized in the chapter.”

“Second, incorporation of trehalose lipid into the phospholipid target membrane gives rise to a fast enzyme inhibition.”

“The C=O stretching band shows that incorporation of trehalose lipid increases the proportion of the dehydrated component in mixtures with the three phospholipids at temperatures below and above the gel to liquid-crystalline phase transition.”

“The hydrophilic nature of trehalose also makes it a water substitute when binding to the phospholipids.”

“This suggested trehalose was useful to incorporate with phospholipids to produce a highly encapsulated and stabilized liposomes of enoxacin.”

“ Trehalose , by contrast, depresses the frequency of the phosphate in dry phospholipids , indicating that the modes of interaction of trehalose and arbutin with the bilayer are different.”

“These modifications of the gel state of hydrated phospholipids by trehalose can only be achieved if a drastic dehydration is performed in the presence of the sugar.”

“Certain sugars, particularly trehalose , dramatically alter physical properties of dry phospholipids in ways that mimic the presence of water.”