Possible Interaction: Phospholipids and Taurine

“The hepatic lipidomics analysis showed that TAU tended to decrease the abundance of individual phospholipids and increase those of some individual TAG and ceramides.”

“Fourth, taurine stabilizes membranes through direct interactions with phospholipids.”

“In rat skeletal muscle, taurine was proposed to interact with a low affinity binding site on sarcolemmal phospholipids near chloride channel, increasing chloride conductance (GCI).”

“For example, taurine has been shown to interact with membrane phospholipids to alter their Ca2+ binding properties7, and may thus influence Ca2+-dependent processes such as ATPase ion pumps, ion channels flux, or Ca2+-activated events5, 6, many of which contribute to neurosecretion and phototransduction.”

“It has been proposed that many pharmacological actions of taurine are due to interaction with a low affinity binding site on membrane phospholipids (14).”

“Similarly, phospholipid levels in niacin + AD and taurine + niacin + AD groups were decreased significantly compared to AD alone.”

“A strong correlation was found between the taurine concentration of the synaptosome and phospholipid methylation rates during brain development.”

“One theory which has been proposed as a unifying hypothesis of taurine action, suggests that the effects of taurine are mediated through its interaction with membrane phospholipids.”

“Although the mechanism of taurine inhibition of Flu binding at 0–4°C is unclear, it may be an indirect effect of taurine interaction with membrane phospholipids.”

“ Taurine also reduced the extent of 3H-methyl group incorporation from radioactive methionine into myocardial phospholipids by −45%.”