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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Phospholipids and Squalamine

supplement:

Squalamine

Research Papers that Mention the Interaction

Squalamine , an aminosterol antibiotic isolated from the dogfish shark, creates relatively large defects in phospholipid bilayers , allowing the unrestricted translocation of small molecules across these compromised membranes (B.S. Selinsky, Z. Zhou, K.G. Fotjik, S. R. Jones, N.R. Dollahon, A.E. Shinnar, Biochim.
Biochimica et biophysica acta  •  2000  |  View Paper
Squalamine decreases the size of vesicles containing anionic phospholipid at a lower squalamine/lipid molar ratio than pure PC LUVs.
We suggest that squalamine complexes with phospholipid to form a discrete structure within the bilayers of LUVs, resulting in the transient leakage of small encapsulated molecules.
Biochimica et biophysica acta  •  1998  |  View Paper