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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phospholipids
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Several cooperative mechanisms appear to underlie the anticholestatic action of SAMe , the most important being the restoration of normal hepatocyte membrane fluidity and Na+, K+ ATPase activity, through a reversal of the reduction in phospholipid methylation produced by hepatotoxic agents.”
Role of S-Adenosyl-L-Methionine in the Treatment of Intrahepatic Cholestasis“The administration of SAM improves the removal of triacylglycerol from ethanol-intoxicated livers and produces modifications of the pools of some hydrosoluble phospholipid precursors.”
“The elevated free cholesterol to phospholipid molar (C/PL) ratio of the erythrocyte membranes of the patients (0.857 ± 0.018) significantly decreased after the administration of SAMe (1 week, 0.823±0.021; 2 weeks, 0.823±0.013).”
“ S-Adenosylmethionine is involved in many methylation reactions, including methylation of membrane phospholipids , which influences membrane properties.”
“Triglyceride and phosphatide concentrations determined 1, 2, 3 and 4 hours after SAMe administration have shown a decrease in blood triglycerides and an increase in phosphatide levels, with significant values for the subjects with the primary form.”
“Incorporation of [3H]methyl groups into phospholipids increased with membrane concentration and incubation time with S-adenosyl-L-methyl [3H]methionine ; it was not Mg2+ dependent and was inhibited in a dose-dependent manner by S-adenosyl-L-homocysteine, methyltransferase inhibitor.”
Estradiol activates methylating enzyme(s) involved in the conversion of phosphatidylethanolamine to phosphatidylcholine in rat pituitary membranes.“However, incubation of inner medullary microsomes with S-adenosyl-L-methionine under conditions leading to phospholipid methylation increased both Ca2+ responsive phospholipase A2 and C activities approximately twofold.”
“Both the substrate and the competitive inhibitor of the methylation reaction, S-adenosylmethionine and S-adenosylhomocysteine, had profound effect on the rate of phospholipid methylation, without having comparable effects on Ca2+ uptake.”
“On the other hand, after phospholipid methylation in cardiac membranes was stimulated by pre-incubation with S-adenosyl-L-methionine for 60 min at 37 degrees C, [125I] iodohydroxybenzylpindolol binding to the membranes was increased.”
“A significant incorporation of methyl groups into phospholipids occurred not only with methionine but also with SAM.”
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