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Last Updated: 3 years ago

Possible Interaction: Phospholipids and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

In contrast, these three drugs were unable to modify phosphatidylserine synthesis, indicating that the K+ channel blockers, quinine and quinidine , specifically interfere with the synthesis of this phospholipid.
Pharmacology  •  1993  |  View Paper
Quinidine also inhibited both the positive inotropic response and concomitant increase in tissue N-methylated phospholipids observed upon l-methionine perfusion of rat heart.
These results suggest that quinidine alters the intramembranal level of N-methylated phospholipids , and this may serve as a biochemical mechanism contributing to its negative inotropic effect.
Journal of cardiovascular pharmacology  •  1989  |  View Paper
Based on these observations, it was concluded that some species of phospholipids had an important and determining role in the tissue distribution of quinidine in vivo.
Journal of pharmacobio-dynamics  •  1986  |  View Paper
Quinidine strongly perturbs the molecular organization of lipid bilayers prepared from acidic phospholipids (phosphatidylserine, phosphatidic acid) and has only a slight effect on neutral phosphatidylcholine membranes.
Biochimica et biophysica acta  •  1982  |  View Paper