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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phospholipids
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“ PIP2 also increased the spontaneous solubilization of phospholipid liposomes by apoA1.”
PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.“We report that PIP2 can redistribute intracellular cations and thereby lead to a loss of phospholipid asymmetry.”
“ Phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate activate PLD1a and 1b but a range of other acidic phospholipids are ineffective.”
“Addition of PtdIns(4,5)P2 increased PLD activity in HEK cell membranes by 2-3-fold, whereas various other phospholipids were ineffective.”
“Increasing the molar ratio of anionic phospholipid by adding phosphatidylserine, additional PtdIns(4,5)P2 , or by situating PtdIns(4,5)P2 in a more physiologically relevant lipid background increased the apparent association rate constant less than 2-fold.”
Kinetics of the Interaction of myo1c with Phosphoinositides*“However, soybean phospholipids asolectin and phosphatidylinositol-4,5-bisphosphate [ PtdIns(4,5)P2 ] strongly inhibited the binding activity.”
“Analysis of the dependence of … free Ca2+ concentration showed that acidic phospholipids increased Vmax and lowered the apparent Km for free Ca2+ … upon tryptic cleavage of the CaM-binding domain; in particular, PIP2 was shown to lower the apparent Km for … the Ca2+-ATPase also in trypsin-treated PM.”
Stimulation of plant plasma membrane Ca2+-ATPase activity by acidic phospholipids.
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