Possible Interaction: Phospholipids and Phosphatidylethanolamine

“ PE may undergo turnover by the phospholipid : diacylglycerol acyltransferase Lro1p as first step in acyl chain remodeling.”

“Addition of short-chain phospholipids to the gramicidin S-DNA-dioleoyl phosphatidylethanolamine complex enhanced up to 6-fold beta-galactosidase expression in several cell-lines in vitro.”

“The membrane-associated enzyme showed a 2- to 3-fold preference for phosphatidylethanolaminc over phosphatidylcholine hydrolysis when acting on endogenous mitochondrial phospholipids (Fig. 1 ).”

“Moreover, phosphatidylethanolamine content in phospholipid became three times higher than that without Etn in the medium.”

“Conical lipids, phosphatidylethanolamine and diacylglycerol, enhanced transporter activity up to 3-fold in the presence of anionic phospholipids but did not stabilize protein structure.”

“Fractional analysis of total phospholipids revealed significantly increased phosphatidylethanolamine.”

“It seems valuable to carry on further searches for these antibodies in SLE, since patients with aPEA are at higher risk of thrombosis and/or recurrent fetal losses than are patients with antiphospholipid antibodies (anticardiolipin, anti-anionic phospholipid and/or lupus anticoagulant) other than aPEA.”

“Although incubation of dimyristoylphosphatidylcholine (DMPC) with apolipoprotein A-I at the gel-liquid crystalline phase transition temperature results in the … of lipid-protein complexes, the presence of proportionately small amounts of PE prevents the formation of such complexes, suggesting that PE profoundly alters the … properties of the phospholipid bilayers.”

“There is a large decrease in rate when phosphatidylethanolamine constitutes 50 mol% of donor phospholipids.”

“Total phospholipids extracted from platelets inhibited aCL activity, and the specific phospholipids bound were shown to be phosphatidylethanolamine , phosphatidylserine, and phosphatidylinositol.”