Possible Interaction: Phospholipids and Long Chain Fatty Acid

“7) Long-chain 3-thia fatty acids change the fatty acid composition of the phospholipids : in heart, the content of n-3 fatty acids increases and n-6 fatty acids decreases. (”

“It was shown that the quantity of short chain fatty acids decreased and the amount of long chain fatty acids increased in the content of phospholipid fraction.”

“Inhibition of the biosynthesis of long-chain n−6 fatty acids was reflected in a decrease in arachidonic acid (20∶4n−6) content of serum lipids when fasting, and also in the phospholipid fatty acids of liver microsomes.”

“At 4 or 25 degrees C, these phospholipids modified essentially the substrate affinity of the enzyme by increasing the Michaelis constant proportionally to the length of the fatty acid chain.”

“ Long chain fatty acids were found in a higher concentration in the phospholipids of cortex and outer medulla (about 95%) in comparison to the inner medulla (65%).”

“Anaerobic digestion of lipid-containing wastes for biogas production is often hampered by the inhibitory effect of long-chain fatty acids (LCFAs).”

“In contrast, if phospholipids with longer fatty acid chains (distearoylphosphatidylcholine/-glycerol) were used, phase transitions were well above body temperature even at high drug load.”

“Oleic acid and other long chain free fatty acids [saturated (C12-18) and unsaturated (C18)] dose-dependently increased mobilities of lipids in LUV ( phospholipid and cholesterol) and cholesterol transfer rates, whereas short (C8-10) and very long (C24) chain free fatty acids did not.”

“Both kinetics and extent of solubilization were independent of the phospholipid head group , but were significantly affected by the fatty acid chain length.”

“All except the C26-CBS/diC14-PC mixture had eutectic phase behavior at low CBS concentrations suggesting that the long fatty acid chain of the CBS species had a destabilizing effect on the gel phase of most of the phospholipids.”