Possible Interaction: Phospholipids and Iron, Dietary

“Ferroptosis is a recently characterized cell death phenotype resulting from iron catalyzed peroxidation of polyunsaturated fatty acid (PUFA) phospholipids.”

“LOOH molecules and iron ions at the cell wall of an injured cell are in tight contact with phospholipids of neighboring cells and transfer to these reactive radicals.”

“First, catechols (including dopa and dopamine) and iron form strong oxidizing complexes and induce lipid peroxidation (LPO) in phospholipid liposomes.”

“Searching for physiologically relevant lipid regulators of Cygb, here we report that anionic phospholipids , particularly phosphatidylinositolphosphates, affect structural organization of the protein and modulate its iron state and peroxidase activity both conjointly and/or independently of cysteine oxidation.”

“Cellular accumulation of ionic iron leads to peroxidative decomposition of organelle membrane phospholipids with the consequence of cell degeneration and cell death.”

“ Acidic phospholipids , such as phosphatidylinositol (PI) and phosphatidylserine (PS), were observed to show an inhibited acylation profile in retinas exposed to iron while phosphatidylethanolamine (PE) showed the opposite.”

“In contrast to hypoxia, Ca2+ ionophore and Fe each induced significant PL losses (6 to 15%) despite minimal FFA accumulation or cell death (26 to 27% LDH release).”

“ Dietary iron overload damages membrane phospholipids and decreases microsomal cytochromes P-450.”

“It therefore seemed of interest to investA-gate the synthesis, localization and effects on metabolism of phosphono lipids in Tetrahymena pyriformis grown in the presence of iron.”

“In conclusion, the results obtained indicate that iron ions interact with phospholipid bilayers perturbing their structures.”