Possible Interaction: Phospholipids and Epigallocatechin Gallate

“ Green tea catechins were absorbed more extensively when administered as phospholipid complex rather than as free catechins.”

“ EGCG suppressed the initiation rate and prolonged the lag phase duration of peroxyl radical-induced oxidation in a phospholipid liposome model to a greater extent (p < 0.01) compared to both Trolox and α-tocopherol.”

“In healthy rats, despite the decrease in bile flow, EGCG markedly enhanced biliary secretion of cholesterol and phospholipids.”

“Solubilization of the Na(+),K(+)-ATPase with a nonionic detergent reduced sensitivity to epigallocatechin-3-gallate with an elevation of IC50 to 10 microM. These results suggest that epigallocatechin-3-gallate exerts its inhibitory effect through interaction with plasma membrane phospholipid.”

“ EGCG significantly reduced the increased serum levels of cholesterol, triglycerides, and free fatty acids in the heart and serum phospholipids (PLs) in ISO‐treated rats.”

“It is concluded that EGCG protected the DPPG molecules from degrading upon blue light irradiation, which means that EGCG may be a preventive and therapeutic agent to decrease photosensitivity of phospholipids to blue light oxidative damage, a pathogenic mechanism in skin disorders.”

“As a result, we found out that EGCGs naturally bind to the hydrophilic regions of phospholipids , positioning themselves mostly at the interface between water and lipid phases.”