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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phospholipids
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“CPA toxin consists of two domains, i.e., the phospholipase C active site, which lies in the N-terminal domain amino acid (… 1–250), and the C-terminal region (aa residues 251–370), which is responsible for the interaction of the toxin with membrane phospholipids in … of calcium ions.”
Generation of recombinant baculovirus expressing atoxic C-terminal CPA toxin of Clostridium perfringens and production of specific antibodies“Not only were the Pseudonaja venoms significantly more procoagulant, but they were also much less dependent upon the cofactors calcium and phospholipid.”
“These findings demonstrate the pivotal role of phospholipid AA in modulating erythrocyte and renal transport of calcium and oxalate.”
“Annexin II (AII) belongs to a family of glycoproteins that bind negatively charged phospholipids in the presence of calcium.”
“For alveolar and peritoneal macrophages, increasing calcium concentration enhanced SP-A stimulation of phospholipid uptake.”
“These studies demonstrate that the enhancement of phospholipid uptake in alveolar and peritoneal macrophages by SP-A, but not SP-B is augmented by calcium.”
“… calcium … cellular phospholipid uptake stimulated by SP-A or SP-B. We used isolated rat alveolar and peritoneal macrophages and Vero cells, an African Green Monkey …, and studied the effect of calcium concentrations ranging from 2 microM to 2 mM on cellular uptake of liposomes containing 3H-labeled phosphatidylcholine.”
“Release of arachidonic acid from membrane phospholipids as well as subsequent synthesis and release of vasoconstrictor thromboxane A2 are also regulated by movement of calcium ions.”
“Endothelial cells showed both a thrombin inhibition and an activation of prothrombin in the presence of Ca++ , which was enhanced in the presence of phospholipids.”
“There is evidence that calcium ions may mediate binding between gamma carboxyglutamic acid residues on the amino terminal portion of prothrombin and negatively charged phosphate groups on phospholipid micelles.”
“The results are discussed with reference to the possibility that calcium ions induce conformational changes in membrane phospholipids.”
“ Calcium ions are known to induce anionic phospholipids to cluster, and we propose that clotting proteins assemble preferentially on such anionic lipid‐rich microdomains.”
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