Possible Interaction: Phospholipids and Arachidonate

“The molar fraction of arachidonate (20:4) in phospholipids from monocyte-rich preparations was 62% greater than that of purified granulocytes.”

“… [3H]arachidonate or [14C]glycerol to fMet-Leu-Phe (… of label and mass of individual phospholipids : [3H]arachidonate in phosphatidic acid (PA) increased 500% (120 s), [14C]glycerol incorporation and mass of PA …]arachidonate in PI decreased continuously; these data are compatible with activity of a PI/PA cycle.”

“Indeed, the pathways by which oxidative products of arachidonate are formed may also be influenced by stimulus-specific changes in membrane phospholipids , not the least interesting of which is the generation of phosphatidic acid.”

“As a consequence of this process, the arachidonate levels in membrane phospholipids markedly decrease.”

“The liberation of arachidonate from thyroid phospholipids is Ca2+ dependent.”

“The results suggest that arachidonate turnover in brain phospholipids is more rapid than previously assumed.”

“The polyunsaturated fatty acids docosatetraenoate (22:4) and/or arachidonate (20:4) increased in these phospholipids and in sphingomyelin and phosphatidylinositol (P < 0.05).”

“However, in the microsomal phospholipids , the level of arachidonate (20:4) was depressed by about 50% as compared to the controls.”

“The inhibitory serum readily stimulates increased incorporation of arachidonic acid and palmitic acid into triacylglycerol in the treated cells, while the incorporation of arachidonate into various phospholipids is significantly lowered.”