Possible Interaction: Phospholipids and Adrenocorticotropic Hormone

“These results indicate that ACTH may accelerate the maturation of phospholipids metabolism in infant brains, and the observed change may relate to the efficacy of ACTH treatment against the West syndrome.”

“ ACTH stimulated incorporation of 14C-acetate in the glycerol part of triacylglycerols as well as of the total phospholipids , while CHM and the combination of CHM and ACTH had inhibiting effect on the biosynthesis of the glycerol part of triacylglycerols and of total phospholipids.”

“These results offer further support for our contention that ACTH and insulin increase inositide phospholipid concentrations in their target tissues by a cycloheximide-sensitive mechanism.”

“These findings support our previous contentions that: 1) a labile protein is required for ACTH-induced increases in adrenal phospholipids in the phosphatidate-polyphosphoinositide-polyglycerophospholipid pathway; and 2) these phospholipids are involved in the steroidogenic action of ACTH.”

“Our findings … (a) ACTH increases the … of phospholipid (and their levels) throughout the entire circular pathway, i.e., phosphatidate leads to CDP-diacylglycerol leads to inositides leads to diglycerides … to phosphatidate, and (b) a labile protein may serve to allow entry into a recycling of diglyceride in this pathway.”

“Treatment of rats in vivo with ACTH induced a rapid increase in phosphatide synthesis from diglyceride and ATP in adrenal homogenates, and cycloheximide treatment prevented this increase if given before ACTH and rapidly reversed the increase if given after ACTH.”

“A single injection of ACTH or cortisol causes suppression of phospholipid and cholesterol syntheses and a decrease in their specific radioactivities in the mitochondria.”

“Abstract In a group of rabbits injection of ACTH over 5 days caused a rise in cholesterol, phospholipids and triglycerides (TG) in serum.”

“It was, however, observed that the phospholipid content of the brain increases after a single intraperitoneal injection of corticotropin (ACTH) and decreases afterpr olonged administration of the thyrotropic hormone of the pituitary gland (TSH).”