“Histological results revealed that although celecoxib by itself did not cause notable hepatic damages, it markedly enhanced hepatic fibrosis that had been initiated by PS.”
“Notably, celecoxib enhanced reduction of plasma prostaglandin E(2) (PGE(2)) levels induced by PS.”
“While PS alone did not cause any necrotic change in liver cells, the addition of celecoxib resulted in hepatocellular necrosis in PS-treated animals.”