Possible Interaction: Phosphatidylserine and Calcium Supplement

“First, TRPA1 and the hair cell transducer share a unique set of pore … (block by gadolinium, amiloride, gentamicin, and ruthenium red, a ranging conductance of ∼100 pS … calcium , permeating calcium-induced potentiation followed by closure, and reopening by depolarization), … as a pore-forming subunit of the hair cell transducer.”

“Prominent higher calcium responses were triggered by thapsigargin and bradykinin, indicating that mutant PS modulates the dynamic release and storage of calcium ions in the endoplasmatic reticulum.”

“In addition, the open state probability of a Ca(2+)-activated potassium (K+) channel with a conductance of 82 +/- 3 pS is significantly increased by elevating Ca2+o to 3.0 mM or by application of 100 microM neomycin, both effective CaR agonists.”

“Binding to lipid vesicles made from L-alpha-phosphatidyl-L-serine is enhanced in the presence of millimolar amounts of free calcium.”

“The combination of calcium plus PS increased the phosphorylation of the 20K protein more markedly than either calcium or PS alone.”

“Interestingly, 1,2-DG6 (2.5 μM) and PS (1 μM) with calcium activated the enzyme activity to ∼7 fold.”

“The interaction of calcium with the lipid molecules enhances the molecular packing of the PG and PS lipids.”