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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidylinositol 4,5-Diphosphate
drug:
Methacholine
Research Papers that Mention the Interaction
“Moreover, following steady‐state labelling of … lipids with [3H]inositol, methacholine in the presence of 10 mM LiCl caused … fall of 13% in the radiochemical concentration of phosphatidylinositol 4,5‐bisphosphate after only 30 s stimulation and a fall of …% in the radiochemical concentration of phosphatidylinositol after 30 min.”
“When parotid cells … stimulated with methacholine , D-myo-inositol 1,4,5-trisphosphate, …-myo-inositol 1,3,4,5-tetrakisphosphate, D-myo-inositol 1,4-bisphosphate , and D-myo-inositol 4-monophosphate levels increased within 2 s, whereas D-myo-inositol 1-monophosphate accumulation was delayed by several seconds.”
Source of 3H-labeled inositol bis- and monophosphates in agonist-activated rat parotid acinar cells.“The muscarinic cholinergic agonist methacholine caused a rapid loss of 15% of [32P]phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and a rapid increase in [32P]phosphatidic acid (PtdA).”
“Stimulation of cholinergic-muscarinic receptors with methacholine provoked a rapid disappearance of 40--50% of [32P]PtdIns(4,5)P2 , but had no effect on PtdIns4P.”
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