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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidylinositol 4,5-Diphosphate
drug:
Gentamicin
Research Papers that Mention the Interaction
“Furthermore, it was shown that the ototoxic aminoglycoside gentamicin has a selective and extremely high binding affinity to PIP2.”
[Hearing loss caused by aminoglycoside antibiotics: affect on the membrane component PIP2 in outer hair cells as the mechanism of action].“Electron spray ionization mass spectrometry (ESI-MS) confirmed earlier observations that gentamicin strongly binds to L-alpha-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), a membrane lipid rich in arachidonic acid.”
“Peroxidation of PtdIns(4,5)P2 by ferrous ions significantly increased in the presence of gentamicin , and EI-MS measurements indicated that oxidative damage to PtdIns(4,5)P2 was accompanied by the release of arachidonic acid.”
Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species.
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