Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago

Possible Interaction: Phosphatidylinositol 4,5-Diphosphate and Doxorubicin Hydrochloride

supplement:

Phosphatidylinositol 4,5-Diphosphate

drug:

Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

“The release rate of DOX slows down with increasing hydrophobic block length of PIPP.”
Micelles from amphiphilic block copolyphosphates for drug delivery.
Macromolecular bioscience  •  2011  |  View Paper
“ ADR alone and in combination with PMA was found to decrease both 32P labeling and lipid phosphate content of phosphatidylinositol 4,5-bisphosphate (PIP2).”
Regulation of the activity and phosphorylation of the plasma membrane Ca(2+)-ATPase by adriamycin in intact human erythrocytes.
Archives of biochemistry and biophysics  •  1995  |  View Paper
“The turnover of 32P and lipid phosphate in phosphatidylinositol 4,5-bisphosphate (PIP2) was inhibited by 1 mM adriamycin , concomitant with an increased amplitude of the [Ca2+]i transient.”
Regulation of the activity and phosphorylation of the plasma membrane Ca(2+)-ATPase by protein kinase C in intact human erythrocytes.
Archives of biochemistry and biophysics  •  1993  |  View Paper
“The data suggested that Adriamycin inhibited a discrete pool of PtdIns(4,5)P2 which may be responsible for the maintenance of a discocyte morphology.”
Inhibition of human erythrocyte inositol lipid metabolism by adriamycin.
Cancer research  •  1987  |  View Paper