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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Phosphatidylinositol 4,5-Diphosphate and Aluminum Chloride

Research Papers that Mention the Interaction

AlCl3 (100 microM) did inhibit rat cortical PI-PLC hydrolysis of PIP2 in a competitive manner.
We have shown previously that aluminum chloride (AlCl3, 10-500 microM) inhibits hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphatidylinositol-specific phospholipase C (PI-PLC) in a concentration-dependent manner.
Toxicology and applied pharmacology  •  1996  |  View Paper
In cortical …, AlCl3 (10-500 microM) inhibited hydrolysis of [3H]phosphatidylinositol 4,5-bisphosphate (PIP2) by PiPLC in a concentration-dependent manner with an estimated IC50 of 100 microM. The effects of AlCl3 on modulation of IP accumulation by extracellular Ca2+ and PKC were also examined as potential mechanisms.
Biochemical pharmacology  •  1994  |  View Paper