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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidic Acid
drug:
Vancomycin
Research Papers that Mention the Interaction
“We suggest that increased levels of phosphatidic acid change the physical properties of the outer membrane to impede entry of vancomycin into the periplasm, hindering access to its target, an intermediate required for the synthesis of the peptidoglycan cell wall.”
“We use genetics and quadrupole time of flight (Q-TOF) liquid chromatography-mass spectrometry (LC-MS) to show that accumulation of phosphatidic acid by means other than cdsA mutations also increases resistance to vancomycin.”
Accumulation of Phosphatidic Acid Increases Vancomycin Resistance in Escherichia coli
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