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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidic Acid
drug:
Trifluoperazine
Research Papers that Mention the Interaction
“ Trifluoperazine (TFP) in concentrations up to 10-15 microM increased the formation of phosphatidic acid (PA) in platelets treated with 0.5 U/ml of thrombin, while higher concentrations of TFP inhibited formation of PA.”
Trifluoperazine enhances accumulation and inhibits phosphohydrolysis of phosphatidate in thrombin-stimulated platelets.“ TFP decreased [1-14C]-fatty acid incorporation into phosphatidylcholine, phosphatidylethanolamine and triacylglycerol, but greatly increased14C-labeling in phosphatidic acid.”
Modulation of fatty acid incorporation and desaturation by trifluoperazine in fungi“In addition to phosphatidylethanol, basal phosphatidic acid levels were also increased after calmidazolium and trifluoperazine addition.”
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