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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidic Acid
drug:
Theophylline
Research Papers that Mention the Interaction
“In cells in which the phosphatidylcholine pool …-glycero-3-phosphocholine, prostaglandin E2 plus theophylline … [3H]phosphatidic acid and its subsequent conversion to [3H]diradylglycerol, implying an effect at the level of phospholipase D. … of [3H]phosphatidylcholine to generate [3H]phosphatidylethanol (a phospholipase D-dependent reaction) was also markedly inhibited.”
Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation.“Concentrations of dibutyryl cyclic AMP and theophylline fully inhibitory for the metabolic responses inhibited phosphoinositide breakdown and phosphatidic acid formation to a large extent.”
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