“The concentration dependence for the formation of PA induced by SPP correlated with its effect on DNA synthesis.”
“Thus, in addition to its … on mobilization of calcium, SPP can increase … level of PA , most likely via activation of phospholipase D. We suggest that SPP mediates the effect of sphingosine on PA accumulation in Swiss 3T3 fibroblasts and may regulate cellular proliferation by affecting multiple transmembrane signaling pathways.”