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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phosphatidic Acid
drug:
Sirolimus
Research Papers that Mention the Interaction
“Importantly, we found that modulation of MTOR activity by treatment with rapamycin and phosphatidic acid had strong effects on the neurodegenerative phenotypes of TBPH (Drosophila TARDBP)-depleted flies.”
TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners“Since PA can interfere with the ability of rapamycin to bind mTOR, the use of combined strategies to target mTOR and PLD activity might be considered to treat HPV-related malignancies.”
“Therefore, elevated levels of PA , which is common in cancer cells, increases the level of rapamycin needed to suppress both mTORC1 and mTORC2.”
“Previously, it has been shown that PA directly interacted with mammalian target of rapamycin and positively regulated the ability of mammalian target of rapamycin to activate downstream effectors.”
“Suppressing PA production substantially increased the sensitivity of mTORC2 to rapamycin.”
“The effect of PA was competitive with rapamycin —with much higher concentrations of rapamycin needed to compete with the PA-mTORC2 interaction than with PA-mTORC1.”
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