Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Phosphatidic Acid and Quinacrine

Research Papers that Mention the Interaction

Such synthesis of lysophosphatidic acid can be inhibited by mepacrine , an inhibitor of the phospholipase A2 which attacks phosphatidic acid to give lysophosphatidic acid.
…,mepacrine … phosphatidic acid in response to thrombin, consistent with some simultaneous inhibition of phospholipase C. Lysophosphatidic acid (2.5-22 microM) overcame the mepacrine block in … without stimulating the release of arachidonic acid from platelet phospholipids or the formation of lysophosphatidic acid, and only slightly increasing phosphatidic acid formation.
Biochimica et biophysica acta  •  1985  |  View Paper
Quinacrine (1 mM) caused 41% reduction in the amount of [3H]phosphatidic acid accumulated by the stimulation in [2-3H]glycerol-prelabeled cells.
Biochimica et biophysica acta  •  1983  |  View Paper
The SRE stimulation by PA was dramatically reduced by either pre-treatment with mepacrine , an inhibitor of phospholipase A2 (PLA2), or co-transfection with antisense cytosolic phospholipase A2 (cPLA2) oligonucleotide, whereas lysophosphatidic acid (LPA)-induced SRE activation was not affected.
Biochemical and biophysical research communications  •  1998  |  View Paper
Quantitative analysis of these mepacrine effects, together with the known inhibitory effects of this compound on phospholipase A2 and phosphatidylinositol-specific phospholipase C, suggests that mepacrine also inhibits phosphatidic acid phosphatase, thereby shunting the flux of phosphatidic acid away from diglyceride formation and into synthesis of phosphatidylinositol.
Biochemical pharmacology  •  1983  |  View Paper
Mepacrine stimulated the labelling of phosphatidic acid , phosphatidylinositol and diacylglycerol, and inhibited that of phosphatidylcholine, phosphatidylethanolamine and triacylglycerol.
Biochimica et biophysica acta  •  1982  |  View Paper