Possible Interaction: Phosphatidic Acid and Propranolol

“In the absence of the ligand, the inhibition of phosphatidic acid phosphohydrolase activity by propranolol treatment leads to internalization of empty/inactive receptors.”

“In contrast, inhibition of PA hydrolysis with propranolol enhanced fMLF-mediated VAT-1 recruitment to membranes.”

“Moreover, PA and TNF-alpha-induced expression of CD83 was slightly increased by propranolol , an inhibitor of PA phosphohydrolase but was unaffected by phospholipase A2 inhibitor.”

“ Propranolol , known to increase phosphatidic acid levels, was ineffective in reversing the G2/M-phase arrest in TD fibroblasts.”

“ Propranolol , an inhibitor of phosphatidic acid phosphohydrolase, increased the carbachol-induced formation of phosphatidic acid at the expense of 1,2-diacylglycerol.”

“Further studies evaluated the inhibitory effect of propranolol on phosphatidic acid (PA) phosphohydrolase, which converts PA to diacylglycerol in various type of cells (2).”

“ Propranalol , which increases PA accumulation by inhibiting PA phosphohydrolase, lowered PMN O2 ‐ responses to hyphae.”

“ DL-Propranolol , a PA phosphohydrolase inhibitor, caused an accumulation of PA , without affecting DAG formation in either vitamin E-treated and untreated cells.”

“Since several molecular species of phosphatidic acid (PA) produced an inhibition of both PAF production and acetyltransferase activation on intact cells, a portion of the inhibitory effect of propranolol was related to the accumulation of PA.”

“ Propranolol , an inhibitor of diacylglycerol formation from phosphatidic acid , caused a prolonged transmembrane influx of Ca2+ and partially reversed the inhibitory effect of ethanol on FMLP-induced O2- production.”