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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Phosphatidic Acid
drug:
Phospholipids
Research Papers that Mention the Interaction
“Analysis of retinal phospholipids revealed a reduction in phosphatidic acid ( PA ) levels and an associated reduction in phosphatidylinositol (PI) levels.”
lazaro Encodes a Lipid Phosphate Phosphohydrolase that Regulates Phosphatidylinositol Turnover during Drosophila Phototransduction“ Phosphatidic acid is also involved in the synthesis of phospholipids and its loss will result in changes to the lipid composition of the inner mitochondrial membrane.”
“ Phosphatidic acid at a molar ratio of 20 mole percent produces a marked decrease in Km for phospholipid and for calcium (Km ∼ 20 μM).”
“In particular, the levels of phosphatidic acid , key precursor of phospholipid synthesis, increased, whereas those of mitochondrial cardiolipin (CL) decreased; in parallel, phospholipid remodeling was induced.”
Palmitate lipotoxicity in enteric glial cells: Lipid remodeling and mitochondrial ROS are responsible for cyt c release outside mitochondria.“We perturbed phospholipid synthesis by activating phospholipase D with sphingosine 1-phosphate (S1P) or inhibiting phosphatidic acid phosphohydrolase by propranolol (Ppl).”
“Upon administration of this phospholipid , the intracellular levels of phosphatidic acid ( PA ) rise with a time course that parallels that of the Ca2+ mobilization, suggesting that PA could be responsible for this Ca2+ signal.”
“Since PA is an important intermediate for de novo biosynthesis of phospholipids , these results reveal a novel mechanism for promoting synthesis of PA enriched in polyunsaturated fatty acids in brain.”
“Among phospholipids , the uptake of isotope into phosphatidic acid was higher at nearly all ages examined.”
“In both hyperoxic liver and kidney microsomes, phospholipid content decreases in agreement with the depression of phosphatidic acid biosynthesis.”
“When the acidic phospholipids phosphatidylserine and phosphatidic acid were incorporated into both vesicles and microemulsions at up to 10 mol % of the total phospholipid , a dose-dependent reduction in the apparent Km was observed.”
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