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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Phosphatidic Acid
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“ Phosphatidylinositol 4,5-bisphosphate and phosphatidic acid synergistically stimulated GAP activity.”
AGAP1, an Endosome-associated, Phosphoinositide-dependent ADP-ribosylation Factor GTPase-activating Protein That Affects Actin Cytoskeleton*“ PA enhanced PLC-delta3 activity by increasing the Vmax and lowering Km for PtdInsP2.”
“Preloading Golgi membranes with short chain phosphatidic acid abrogated the alcohol-mediated inhibition of PtdIns(4,5)P2synthesis in vitro.”
Fragmentation of the Golgi Apparatus“ PA and PS had no effect by themselves but PA increased GAP2 activity in the presence of PIP2.”
“The activation by PA was completely suppressed by phosphatidylinositol 4,5-bisphosphate (PIP2).”
“The decrease in phosphatidylinositol 4,5-bisphosphate and phosphatidic acid was transitory but phosphatidylinositol 4-monophosphate levels remained lower in the BBM at 2 weeks after uNX compared to control membranes.”
“However, VIP enhanced the TRH-induced hydrolysis of PIP2 , the conversion of phosphatidylinositol 4-phosphate (PIP) to PIP2 and the accumulation of phosphatidic acid (PA).”
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